Protein Details: Aquaporin-2

Protein ID

ICDB_Pro_0699

Protein Name

Aquaporin-2

Gene Name

AQP2

Organism

Canis lupus familiaris (Dog) (Canis familiaris)

Length

109 amino acids

AlphaFoldDB

AF-P79144-F1-model_v4.pdb

Function

Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water; thereby permitting water to move in the direction of an osmotic gradient.

Sequence

SVAFSRAVFAEFLATLLFVFFGLGSALNWPQALPSVLQIAMAFGLGIGTLVQALGHVSGAHINPAVTVACLVGCHVSFLRAAFYVAAQLLGAVAGAALLHEITPPHVRG

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

DOI ID

10.1093/oxfordjournals.molbev.a025772